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Engineered T Cell Therapies from a Drug Development Viewpoint Review

Fang Chen, Joseph A. Fraietta, Carl H. June, Zhongwei Xu, J. Joseph Melenhorst, Simon F. Lacey

Engineering 2019, Volume 5, Issue 1,   Pages 140-149 doi: 10.1016/j.eng.2018.11.010

Abstract: Anti-CD19 chimeric antigen receptor T cells (CART19) have demonstrated a remarkable degree of clinicalThe process of developing CART19 essentially follows the conventional “one gene, one drug, oneThis article reviews the use of biomarker-based assays to guide the optimization of CAR constructs, preclinicalstudies, and the evaluation of clinical efficacy; adverse effects (AEs); and CART19 cellular kineticsAdvanced technologies and computational tools that enable the discovery of optimal targets, novel CAR

Keywords： Engineered T cell therapies     Chimeric antigen receptor     Drug development process     Biomarkers     CAR19     CART19    

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Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Frontiers of Medicine doi: 10.1007/s11684-023-1010-1

Abstract: Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Keywords： exosomes induce activation     impair function CD19     exosomal CD19 antigen    

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Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 285-294 doi: 10.1007/s11684-021-0843-8

Abstract: Anti-CD19 chimeric antigen receptor (CAR) T cell therapy has shown impressive efficacy in treating B-celldose-escalation study was conducted to evaluate the safety and efficacy of T cells transduced with CBM.CD19CAR, a second-generation anti-CD19 CAR bearing 4-1BB costimulatory molecule, for the treatment of patientsTen heavily treated patients with refractory DLBCL were given CBM.CD19 CAR-T cell (C-CAR011) treatmentThe overall response rate was 20% and 50% at 4 and 12 weeks after the infusion of C-CAR011, respectively

Keywords： CAR-T cell therapy     refractory diffuse large B-cell lymphoma     cytokine release syndrome     dose-limiting    

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The Status and Problems in Developing Private Use Car for China

Guo Konghui

Strategic Study of CAE 2000, Volume 2, Issue 8,   Pages 25-30

Abstract:

Should China develop its private use car? What kind of passenger car should China develop?Should China develop its own passenger car industry?What is the way out for China´s passenger car industry?And how to develop Chinese passenger car industry?to solve the“auto disaster”problems is not to put more restrains on the use of private car

Keywords： Chinese auto industry     private use car     family use car     state and problems    

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CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Frontiers of Medicine 2017, Volume 11, Issue 4,   Pages 554-562 doi: 10.1007/s11684-017-0543-6

Abstract:

T cells engineered with chimeric antigen receptor (CAR) have been successfully applied to treat advancedThe immunosuppressive nature of tumor microenvironment is considered one of the key factors limiting CAR-TWe successfully generated LAG-3 knockout T and CAR-T cells with high efficiency using LAG-3 knockout CAR-T cells displayed robust antigen-specific antitumor activity incell culture and in murine xenograft model, which is comparable to standard CAR-T cells.

Keywords： CAR-T     CRISPR-Cas9     LAG-3    

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Thermal response of steel framing members in open car park fires

Xia YAN; Marion CHARLIER; Thomas GERNAY

Frontiers of Structural and Civil Engineering 2022, Volume 16, Issue 9,   Pages 1071-1088 doi: 10.1007/s11709-022-0879-0

Abstract: For open car park structures, adopting a performance-based structural fire design is often justifiedthis design approach requires an accurate assessment of temperatures in structural members exposed to carThis paper describes a numerical study on the thermal exposure on steel framing members in open car parkResults show that temperatures in unprotected beams and columns are influenced by the section geometry, car

Keywords： open car park     localized fire     steel frame     numerical modeling     computational fluid dynamics    

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Electric Car Market Poised to Accelerate

Chris Palmer

Engineering 2021, Volume 7, Issue 2,   Pages 136-138 doi: 10.1016/j.eng.2020.12.009

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CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 783-804 doi: 10.1007/s11684-021-0904-z

Abstract: Chimeric antigen receptor T-cell (CAR T) immunotherapy opens a new path for targeted therapy of hematologicalIn this review, through a representative case study, we summarize the current experience of CAR T-celleffects, the causative mechanisms of therapy resistance, and new strategies to improve the efficacy of CAR

Keywords： CAR T cells     hematological malignancies     review    

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The engineering and technology progress of CAR-CA

Zhao Qinping

Strategic Study of CAE 2009, Volume 11, Issue 10,   Pages 25-31

Abstract: To meet the requirement of the design and manufacture of commercial aircraft in China, CAR-CA(collaborativeThis paper introduced the engineering and technology progress of CAR-CA, including the system architecture

Keywords： augmented reality     collaboration     cockpit     design     maintenance    

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A fully solid-state cold thermal energy storage device for car seats using shape-memory alloys

Frontiers in Energy 2023, Volume 17, Issue 4,   Pages 504-515 doi: 10.1007/s11708-022-0855-3

Abstract: characteristics, the design of the shape-memory alloy based the cold thermal energy storage system for precooling cartemperature, elastocaloric materials, and the shape-memory alloy geometry scheme on the performance of car

Keywords： shape-memory alloy (SMA)     elastocaloric effect (eCE)     cooled seat     cold thermal energy storage    

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A review of the safety and efficacy of current COVID-19 vaccines

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 39-55 doi: 10.1007/s11684-021-0893-y

Abstract: Vaccination is the most effective and feasible way to contain the coronavirus disease 2019 (COVID-19)The rapid development of effective COVID-19 vaccines is an extraordinary achievement.reviewed the efficacy/effectiveness, immunogenicity, and safety profile of the 12 most progressed COVID-19

Keywords： COVID-19     SARS-CoV-2     vaccine     safety     efficacy     effectiveness     immunogenicity    

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Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 726-745 doi: 10.1007/s11684-020-0746-0

Abstract: Chimeric antigen receptor (CAR) T cells have been indicated effective in treating B cell acute lymphoblasticHowever, CAR T cells have achieved minimal success against solid malignancies because of the additionalIn this review, we focus on the recent advances in the engineering of CAR T cell therapies to restorethe immune response in solid malignancies, especially with CAR T cells acting as cellular carriers tothe anti-tumor outcomes of CAR T cell therapies in solid tumors.

Keywords： CAR T cells     immunoregulatory molecules     endogenous immune response     solid malignancies    

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Innovation-driven trend shaping COVID-19 vaccine development in China

Frontiers of Medicine doi: 10.1007/s11684-023-1034-6

Abstract: Confronted with the coronavirus disease 2019 (COVID-19) pandemic, China has become an asset in tacklingprotein of SARS-CoV-2 or inactivated whole virus are a cornerstone of the public health response to COVID-19

Keywords： SARS-CoV-2     COVID-19 vaccine     vaccine development    

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CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 322-338 doi: 10.1007/s11684-021-0901-2

Abstract: To date, six chimeric antigen receptor T cell (CAR-T) therapies have been permitted for the treatmentHowever, several clinical trials of solid tumor CAR-T therapies were prematurely terminated, or theyaberrantly glycosylated glycoforms of tumor-associated antigens can also minimize the off-tumor effects of CAR-Tdiscuss how underglycosylated antigens emerge and then detail the latest advances in the development of CAR-T-based

Keywords： cancer immunotherapy     chimeric antigen receptor     solid tumors     tumor-associated antigen     glycosylation     O-glycans     adoptive cell therapy    

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SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

Frontiers of Medicine 2022, Volume 16, Issue 2,   Pages 185-195 doi: 10.1007/s11684-021-0913-y

Abstract: genomic sequence with the world, has greatly facilitated the development of coronavirus disease (COVID-19combinations and immunization strategies to provide sufficient and sustainable immune protection against COVID-19

Keywords： COVID-19     pandemics     SARS-CoV-2     vaccination    

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Title Author Date Type Operation

Engineered T Cell Therapies from a Drug Development Viewpoint

Fang Chen, Joseph A. Fraietta, Carl H. June, Zhongwei Xu, J. Joseph Melenhorst, Simon F. Lacey

Journal Article

Tumor-derived exosomes induce initial activation by exosomal CD19 antigen but impair the function ofCD19-specific CAR T-cells via TGF-β signaling

Journal Article

Phase I study of CBM.CD19 chimeric antigen receptor T cell in the treatment of refractory diffuse large

Journal Article

The Status and Problems in Developing Private Use Car for China

Guo Konghui

Journal Article

CRISPR-Cas9 mediated LAG-3 disruption in CAR-T cells

Yongping Zhang, Xingying Zhang, Chen Cheng, Wei Mu, Xiaojuan Liu, Na Li, Xiaofei Wei, Xiang Liu, Changqing Xia, Haoyi Wang

Journal Article

Thermal response of steel framing members in open car park fires

Xia YAN; Marion CHARLIER; Thomas GERNAY

Journal Article

Electric Car Market Poised to Accelerate

Chris Palmer

Journal Article

CAR T-cell immunotherapy: a powerful weapon for fighting hematological B-cell malignancies

Journal Article

The engineering and technology progress of CAR-CA

Zhao Qinping

Journal Article

A fully solid-state cold thermal energy storage device for car seats using shape-memory alloys

Journal Article

A review of the safety and efficacy of current COVID-19 vaccines

Journal Article

Programming CAR T cells to enhance anti-tumor efficacy through remodeling of the immune system

Xiaohui Wang, Zhiqiang Wu, Wei Qiu, Ping Chen, Xiang Xu, Weidong Han

Journal Article

Innovation-driven trend shaping COVID-19 vaccine development in China

Journal Article

CAR T cells redirected against tumor-specific antigen glycoforms: can low-sugar antigens guarantee a

Journal Article

SARS-CoV-2 vaccine research and immunization strategies for improved control of the COVID-19 pandemic

Journal Article